Internet Explorer is a web designer/developer's biggest headache. It's behind the times, it doesn't support the latest CSS3 techniques and causes people like me to spend hours, nearly in tears, trying to get designs to look good in Microsoft's browser.
All of the other browsers listed below, are faster, safer, and even look better than Internet Explorer.
(And if you're a Microsoft fanboy, and insist on using Internet Explorer, please upgrade to version 9.)